Sila Cagri Isler

Peri-implantitis is a growing public health problem with its higher prevalence, non linear accelarating pattern of progression, and unclear predisposing factors. It represents one of the most challenging problems of the contemporary implant dentistry. In reconstructive surgical treatment of peri-implantitis, the additional benefit of using of a resorbable membrane covering the bone substitute material is a topic that has been discussed recently. However, there is limited evidence regarding the long-term outcomes of using the combination of a resorbable collagen membrane and a bone subsitute in the treatment of peri-implant defects. Therefore, we aimed to compare the efficacy of collagen membrane (CM) and concentrated growth factor (CGF) combined with a bone subsitute in reconstructive treatment of peri-implantitis in the short-, medium-, and long-term. To have the long-term stability of treatment success, the components of the regular supportive peri-implant care (SPIC) individually tailored based on the possible risk indicators were explained. A retrospective study was performed to investigate the role of adequate keratinized mucosa (≥2 mm) on the long-term outcomes of the reconstructive treatment during SPIC, and to identify possible predictors in this relationship. Reconstructive peri-implantitis therapy utilizing a bone substitute covered by a barrier membrane with submerged healing accompanying with a strict SPIC protocol can exhibit favorable long-term outcomes. CM in combination with a bone substitute seems to have better radiographic outcomes compared to the CGF membranes in the long-term. However, considering the cost effectiveness, CGF can be also a good option in reconstructive treatment. The presence of an initial adequate keratinized mucosa can be associated with greater radiographic defect fill in the long-term outcomes of reconstructive peri-implantitis therapy. The presence of vestibulum depth≥4 mm and attached mucosa>1 mm, and the deepest PD and the mean PD values at baseline were observed as other significant predictors for reconstructive therapy outcomes.

Dr. Sila Cagri Isler is currently working as an associate professor in the Department of Periodontology, Gazi University, Faculty of Dentistry, Ankara, Turkey. As of this year, she has working and conducting her research as a research associate in the Department of Periodontology, University of Bern, Switzerland. She completed her 4-year-long PhD training in 2015, and did her post-doc programme in 2021-2022 in the Department of Periodontology and Oral Histology, University of Bern, Switzerland. She had been awarded to work in the same department as the Osteology ART fellow in 2023.